Being the hub of local commerce and the forward resupply base for expeditions into the unexplored space beyond the Federation's borders, Serenity regularly sees starships of every size and description pass through. Following is a brief list of some of the Starfleet vessel classes assigned to Serenity, and Civilian vessels registered to Serenity residents.
| Starfleet | |
| USS Sutherland | Nebula class |
| USS Falcon | Falcon class |
| USS Prowler | Chimera Class |
| Cat's-Eye class | System patrol craft |
| Yellowstone Class | Runabout |
| Peregrine Class | Medium Strike Fighter |
| Scorpion Class | Armed Scout / Fighter |
| Banshee Class | Light Starfighter |
| Valkyrie Class | Escort Fighter |
| Non-Starfleet | |
| SS Rocinanté | Xenon class light cargo ship |
| SS Colombia | Black Bird class attack cruiser |
| Firefly | Converted Klingon Raptor |
| Mol-Kom | Intrepid Class Aerowing |